The 2011/03/01 at 16:27
Alexandre T. Analis
As harmful as it may be, the mosquito bite is a model of precision: carried out to an ideal depth, it combines the injection of an anticoagulant and the extraction of a dose of blood thanks to five sensors and two pumps in the insect’s makeup. The Eveon company, founded two and a half years ago, in Montbonnot-Saint-Martin (French department of Isère), was born from a somewhat crazy idea: reproducing the mosquito’s technique to elaborate a secure automatic injection system for medicines. Crowned by the Prix Émergence, then the Prix Développement awarded by the Concours National d’Aide à la Création d’Entreprise de Technologies Innovantes (a national competition to encourage the setting up of businesses based on innovative technologies) organised by the French Ministry of Higher Education and Research, the idea became a business project incubated by Grenoble Alpes Incubation (GRAIN). Ever since, other partnerships have been signed with Grenoble INP (a stakeholder of Eveon), Minatec, Minalogic, CEA, Lyonbiopôle…
Single-dose and multi-dose injections
Eveon thus offers the first medical injection system to be fully automatic and secure, that can be generalised for all types of auto-injections. The French company intends to develop many families of single-use or reusable single-dose or multi-dose injection devices: intramuscular, intradermal, and intravenous. The operation takes place in three stages: the device is armed and positioned on the injection site; the needle penetrates the skin and the medicine is injected, all automatically; and finally, the needle retracts and the device locks itself. “A micro-pump allows the injection to take place automatically,” explains Vincent Tempelaere, 45 years old, Chairman of Eveon. “A diode lights up when the device is armed and the injection takes place by itself. When the needle withdraws, the diode changes colour.” The advantages of this system compared with classic injections are obvious: the needle is invisible and remains inaccessible before, during and after the injection – much safer! –, dead volume is reduced to several microlitres, and auto-injections take place in three steps only. “Integrated sensors detect the skin, so the needle’s descent and injection are completely secure,” Valérie Roux-Jallet, 43 years, an engineer in bio-materials and Co-Founder of Eveon. The system is reusable over a two-year period (battery and electronic card); only the medicine cartridge and needle need to be changed at every injection.
For viscous and freeze-dried products
Allowing for all types of molecules to be measured, the device is adapted to all systems (glass flacons or cartridges). The pharmaceutical industry does not need to modify the containers of its molecules The system is also valid for products in viscous or freeze-dried (powdered molecules that need to be rehydrated before injection with a solvent) form, that can be rehydrated in situ, automatically. Eveon offers to develop tailor-made solutions and manufacture injection or sampling devices from the specifications of clients, pharmaceutical or biotechnology laboratories. All solutions are made from a configurable set of “technological bricks” that can be assembled according to precise criteria such as the viscosity of the solution, the duration of the injection, the volume to be injected or sampled, the temperature, the needle, the type and depth of injection or sampling… In order to guarantee medical devices that satisfy client needs and quality assurance requirements, Eveon has set up a quality assurance system that is expected to receive ISO13485 certification at the end of the first quarter this year.
More information on www.eveon.eu
• Founded at the end of 2008
• 14 employees (22 by the end of 2011)
• 7 international patents
Source: Eveon – January 2011